Post translational Modification Creative Peptides

902 views

|

October 15, 2018

  • Share
  • Peptide chemists have a myriad of approaches available to optimize lead peptide structures for activity, potency and the desired selectivity for the target of interest. Thus multiple modifications and/or longer-range structural features (e.g. cyclization) are often necessary to obtain the desired stability. For example, while gonadotropin releasing hormone (GnRH) already contains pyroglutamic acid at the N-terminus and a C-terminal amide, clinically used analogs contain a D-amino acid at position 6 in the middle of the peptide to stabilize the peptides to metabolism as well as modified C-termini.

    Personalized Medicine

    Keep up to date with all your favourite videos and channels.

    Get personalised notifications on new releases and channel content by subscribing to the LabTube eNewsletter.