Pittcon 2015 Seminar: IC-HRAM For Metabolomics

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Chromatography & Mass Spectrometry Solutions

Speaker: Terri Christison Using Ion Chromatography with high resolution accurate mass spectrometry (IC-HRAM) for metabolomics Analyzing small metabolites is necessary to identify biomarkers of certain disease states. Ion chromatography (IC) is an effective technique for separating small, polar metabolites including the TCA and Glycolysis cycle metabolites. Techniques including reversed–phase chromatography and HILIC lack the required selectivity for such applications. Additionally, High-Resolution Accurate-Mass (HR/ AM) mass spectrometry can confirm the identity of the given metabolite. Coupling IC with HR/AM mass spectrometry provides better sensitivity and resolving power to determine a large quantity of polar metabolites. For more information visit here: http://chrom.ms/1NHWEvy