HDX for understanding a protein's higher order structure and function | Behind the Science

808 views

|

September 30, 2018

  • Share
  • How do researchers understand how proteins interact in the body? In #BehindtheScience, Jen meets Waters principal scientist Keith Fadgen. He compares two techniques, x-ray crystallography and hydrogen-deuterium exhange (HDX). X-ray crystallography can be used to determine the atomic and molecular structure of a crystal. HDX can be used to study protein-protein interactions over a course of time, which is useful for common biopharmacuetical studies such as epitope mapping, formulation stability testing, and understanding how diseases and viruses function. Keith explains how Waters collaborated with academic labs to make HDX experiments robust and reliable.

    Analytical TechniquesChromatographyMass Spectrometry

    Keep up to date with all your favourite videos and channels.

    Get personalised notifications on new releases and channel content by subscribing to the LabTube eNewsletter.