LabTube.tv
  • settings
  • CC
  • 360p
  • 480p
  • 720p
  • 1080p
2,421 VIEWS | 1 LIKES

Fragment-based Approach to Multi-target Compounds

from SELECTBIO

The presented work deals with the development of a fragment based strategy for dual-target drug discovery. Here, we applied a modified self-organizing map algorithm for in silico recognition of molecular fragments binding two targets: 5-lipoxygenase and soluble epoxide hydrolase. The predicted properties were confirmed by complementary screening techniques: STD-NMR and enzyme assay. A variety of dual fragments active in both complementary assays could be obtained using self-organizing maps, which was optimized towards nanomolar inhibitory activity against both targets.

about 5 years ago

Recommended Videos
Latest Videos

We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy