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Antibody Drug Conjugates BOC Sciences

from Life Sciences Collection

Antibody-drug Conjugates or ADCs consist of an antibody, a cytotoxic drug, and a linker that attaches the two. Such conjugates exhibit a broadly applicable method to increase the antitumor activity of antibodies and improve the tumor-to-normal tissue selectivity of chemotherapy. An ideal ADC has a selective monoclonal antibody and a highly potent drug, mixed with properly stable linker systems and conjugation technologies that preserve the characteristics of the antibody. ADCs could theoretically be to target just about any biological tumor target as long as it can be reached by internalizing antibodies.

about 1 year ago

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