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Metabolomics Platform for Toxicology Research in Zebrafish

from Technology Networks

The zebrafish model organism is increasingly used for assessing drug and chemical toxicity and safety. Needless to say, the use of zebrafish as a model in different studies is a new analytical challenge as only low amounts of sample are available (different tissues) and extremely low amounts of plasma. In these low sample amounts, determination of dosed chemicals or drugs needs to be performed as well as toxigenomic analyses such as metabolomics. We investigated the applicability of our regular metabolomics platform, and the implementation of new technology, methodology and approaches to improve sample handling and to maintain the excellent performance of these methods for very small sample amounts.

about 9 years ago

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