Cyclin D1 Expression in Penile Cancer | Oncotarget



May 14, 2024

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  • Oncotarget published this research paper on May 14, 2024 in Volume 15, entitled, “Cyclin D1 expression in penile cancer” by researchers from the Postgraduate Program in Adult Health, Federal University of Maranhão, Maranhão, Brazil; Clinical Research Center, University Hospital of the Federal University of Maranhão, São Luís, Brazil; State University of Maranhão, Zé Doca, Brazil; University Hospital, Federal University of Maranhão, São Luís, Brazil; Oncology Research Center, Federal University of Pará, Belém, Brazil; Clinical Hospital of Medical School, São Paulo, State University, Unesp, Botucatu, São Paulo, Brazil; Postgraduate Program in Nursing, Federal University of Maranhão, Maranhão, Brazil; Postgraduate Program in Health Science, Federal University of Maranhão, Maranhão, Brazil; Department of Genetics and Postgraduate Program in Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil; Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. DOI - Correspondence to - Gyl Eanes Barros Silva - Abstract The main goal of the present study was to analyze the expression profile of cyclin D1 in patients with PC, and to determine possible correlations with clinical and histopathological features. A survey was conducted with 100 patients diagnosed with PC, who were treated at two reference hospitals in São Luís, Maranhão, Brazil, between 2013 and 2017. A review of clinical, epidemiological, and histopathological data was performed, Human Papillomavírus (HPV) DNA was detected using polymerase chain reaction (PCR) and cyclin D1 expression analysis was performed using immunohistochemical techniques. The data revealed that the absence of cyclin D1 expression was significantly associated with HPV-positive histological subtypes (p = 0.001), while its expression was associated with high-grade tumors (p = 0.014), histological subtype (p = 0.001), presence of sarcomatoid transformation (p = 0.04), and perineural invasion (p = 0.023). Patients with cyclin D1 expression exhibited lower disease-free survival compared to the cyclin D1-negative group, although the difference was not statistically significant. The results suggest that cyclin D1 may be a potential biomarker for PC, especially for poorer prognosis. Sign up for free Altmetric alerts about this article - Subscribe for free publication alerts from Oncotarget - Keywords - cancer, immunohistochemistry, biomarkers, cyclin D1, penile neoplasms About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit and connect with us: Facebook - X - Instagram - YouTube - LinkedIn - Pinterest - Reddit - Spotify - Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

    Analytical TechniquesCancer Research

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