Chlorogenic Acid Prevents Bone Loss in Ovariectomy Model | Aging-US

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March 21, 2024

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  • Aging-US published this research paper on March 9, 2024, in Volume 16, Issue 5, entitled, “Chlorogenic acid prevents ovariectomized-induced bone loss by facilitating osteoblast functions and suppressing osteoclast formation" by researchers from the Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung 40202, Taiwan; Division of Family Medicine, China Medical University Hsinchu Hospital, Hsinchu 30272, Taiwan; Physical Examination Center, China Medical University Hsinchu Hospital, Hsinchu 30272, Taiwan; Department of Medical Research, China Medical University Hsinchu Hospital, Hsinchu 30272, Taiwan; Department of Pharmacology, School of Medicine, China Medical University, Taichung 40202, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung 40202, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40202, Taiwan; School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung 40202, Taiwan; Department of Chinese Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan; Department of Chinese Medicine, China Medical University Hospital Taipei Branch, Taipei 11449, Taiwan; School of Chinese Medicine, China Medical University, Taichung 40202, Taiwan; Department of Bioinformatics and Medical Engineering, Asia University, Taichung 41354, Taiwan. DOI - https://doi.org/10.18632/aging.205635 Corresponding authors - Wen-Ling Wang - supercocono1@mail.cmu.edu.tw, and Chun-Hsu Yao - chyao@mail.cmu.edu.tw Abstract Osteoporosis is a usual bone disease in aging populations, principally in postmenopausal women. Anti-resorptive and anabolic drugs have been applied to prevent and cure osteoporosis and are associated to a different of adverse effects. Du-Zhong is usually applied in Traditional Chinese Medicine to strengthen bone, regulate bone metabolism, and treat osteoporosis. Chlorogenic acid is a major polyphenol in Du-Zhong. In the current study, chlorogenic acid was found to enhance osteoblast proliferation and differentiation. Chlorogenic acid also inhibits the RANKL-induced osteoclastogenesis. Notably, ovariectomy significantly decreased bone volume and mechanical properties in the ovariectomized (OVX) rats. Administration of chlorogenic acid antagonized OVX-induced bone loss. Taken together, chlorogenic acid seems to be a hopeful molecule for the development of novel anti-osteoporosis treatment. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205635 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, chlorogenic acid, osteoporosis, ovariectomized, osteoclast, osteoblast About Aging-US Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases. Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

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