Parental Age Impact on Longevity in Drosophila and C. elegans | Aging-US



November 20, 2023

  • Share
  • Aging-US published this research paper on November 1, 2023 in Volume 15, Issue 21, entitled, “Parental age effect on the longevity and healthspan in Drosophila melanogaster and Caenorhabditis elegans" by researchers from IM Projet, Neyron, France; Caduceum, Lyon, France; INRA, Centre des Sciences du Goût et de l’Alimentation (CSGA), Dijon, France; IBDM, Parc Scientifique de Luminy, Marseille, France; Instituto Serrapilheira, Rio de Janeiro, Brasil; Institut de Genomique Fonctionnelle de Lyon, UMR5242, Universite Claude Bernard-Lyon 1, Ecole Normale Superieure de Lyon, Lyon, France. DOI - Corresponding author - Anne Laurençon - Abstract Several studies have investigated the effect of parental age on biological parameters such as reproduction, lifespan, and health; however, the results have been inconclusive, largely due to inter-species variation and/or modest effect sizes. Here, we examined the effect of parental age on the lifespan, reproductive capacity, and locomotor activity of genetic isogenic lines of the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster. We found that the progeny of successive generations of old parents had significantly shorter lifespans than the progeny of young parents in both species. Moreover, we investigated the fertility, fecundity, and locomotor activity of C. elegans. Interestingly, both the shorter lifespan and deteriorated healthspan of the progeny were significantly improved by switching to only one generation of younger parents. Collectively, these data demonstrate that the detrimental effect of older parental age on the longevity of the progeny can be reversed, suggesting the existence of a beneficial non–genetic mechanism. Sign up for free Altmetric alerts about this article - Subscribe for free publication alerts from Aging - Keywords - aging, life span, intergenerational plasticity, maternal effect, nematode, drosophila About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at​​ and connect with us: SoundCloud - Facebook - X - Instagram - YouTube - LinkedIn - Pinterest - Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

    Analytical TechniquesCell ScienceMolecular Biology

    Keep up to date with all your favourite videos and channels.

    Get personalised notifications on new releases and channel content by subscribing to the LabTube eNewsletter.