Cholinergic Centro-Cingulate Network in Parkinson Disease and Normal Aging | Aging-US



November 1, 2023

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  • Aging-US published this trending research perspective on October 27, 2023, in Volume 15, Issue 20, entitled, “holinergic centro-cingulate network in Parkinson disease and normal aging" by researchers from the Department of Radiology, University of Michigan, Ann Arbor, MI; Neurology Service and GRECC, Veterans Administration Ann Arbor Healthcare System, Ann Arbor, MI; Morris K. Udall Center of Excellence for Parkinson's Disease Research, University of Michigan, Ann Arbor, MI; Parkinson’s Foundation Center of Excellence, University of Michigan, Ann Arbor, MI; Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Neuropsychology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Neurology, University of Michigan, Ann Arbor, MI. DOI - Corresponding author - Nicolaas I. Bohnen - Abstract Decreased cholinergic binding within the recently identified centro-cingulate brain network robustly has been shown to robustly correlate with the severity of cognitive impairment in Parkinson disease (PD). This network with key hubs within the cingulum, operculum and peri-central cortical regions also correlates with elements of parkinsonian motor impairments, including postural instability and gait difficulties, such as falls or freezing. MRI neuroimaging studies have shown that the anterior midcingulate cortex is a key node for cognitive aspects of movement generation, i.e., intentional motor control. Recent evidence also suggests a novel aspect of organization of primary motor cortex, describing “effector” regions for fine movement control intercalated with interlinked “inter-effector” regions devoted to whole-body control. A distinguishing feature of inter-effector regions is tight linkage to the cingular and opercular regions. Such inter-effector regions have been proposed to be part of a greater somato-cognitive action network necessary for integration of goals and movement. Recent evidence also points to vulnerabilities of cholinergic nerve terminals in the centro-cingulate network in older non-PD adults. These features of normal aging underscore that cortical cholinergic terminal losses in age-associated neurodegenerative disorders are likely not exclusively the result of disease-specific etiologies but also related to otherwise normal aging. Practical implications of this overlap are that addressing disease-specific and general aging etiologies involved in neurodegeneration, may be of benefit in age-associated neurodegenerative disorders where significant cholinergic systems degeneration is present. Sign up for free Altmetric alerts about this article - Subscribe for free publication alerts from Aging - Keywords - aging, centro-cingulate network, cholinergic, cognition, motor, Parkinson disease About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at​​ and connect with us: SoundCloud - Facebook - X - Instagram - YouTube - LinkedIn - Pinterest - Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM


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