Ovarian cancer cell invasion into the mesothelial lining of the peritoneum is a dynamic process over time. Utilizing the xCELLigence real-time cell analyzer, the invasive capacity of ovarian cancer cells in a spheroid-mesothelial cell co-culture model can be quantified over prolonged time periods, providing insights into factors regulating the metastatic process.
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Bilandzic, M., Stenvers, K. L. Assessment of Ovarian Cancer Spheroid Attachment and Invasion of Mesothelial Cells in Real Time. J. Vis. Exp. (87), e51655, doi:10.3791/51655 (2014).