Heterogenity of Cellular Responses to Pertubagens

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SELECTBIO

It is generally assumed in the application of High Content Screening (HCS) that the cellular data exhibit a normal distribution.  When a normal distribution exists, a well average approach to screening is possible.  However, heterogeneity is a common attribute of cells and this can impact the design and implementation of a screen.  A set of Heterogeneity indices (HI’s) have been developed to report out along with mean and standard deviations in screening/profiling data.  Examples from drug discovery and drug development are presented.