The KrosFlo® Research IIi Tangential Flow Filtration System for Low Volume Processing



October 30, 2013

Spectrum Laboratories offers, the KrosFlo Research IIi Tangential Flow Filtration System. The only commercially available system with hold up volumes as low as 1 milliliter. Spectrum's innovative, semi-automated TFF System, is ideal for small volume, R&D scale microfiltration and ultrafiltration. Tangential Flow Filtration is fast becoming the preferred method of large and small scale processing, due to outstanding efficiency and easy scalability compared to centrifugal devices. And, the KRIIi system concentrates and washes, viruses, proteins, nano-particles, and cells, at Low Volumes, with remarkable recovery rates. A recent study published in The Elsevier Journal of Virological Method noted incredibly high concentration yields on lentiviral vectors. By using two simple tangential flow filtration steps, the study was able to produce a 2,000 fold concentration and wash in less than 3 hours, with a recovery rate of over 96%. (2 L of virus supernatant down to 1ml) These extraordinary results were achieved using Spectrum's KRIIi System and proprietary hollow fiber filters. The system is flexible, able to handle 10 L of sample with larger filters, tubing, and reservoirs. Adept enough to process volumes down to 1 mL. What was once thought possible only with larger hard plumbed Stainless Steel systems, with larger holdup volumes, can now be done with significantly smaller volumes. Saving both time and money by reducing the required volume of critical, but expensive samples. Meanwhile, all flowrates and pressure readings are graphed real time, in the KF COMM data collection software. The software also has an auto shutoff function which stops the pump when the desired permeate volume is reached. Additionally, the automatic backpressure valve allows for control of transmembrane pressure even at the lowest volumes. When costs of sample materials remain high ... optimize your process ... with The Kros Flo Research IIi Tangential flow filtration system.

BioengineeringBioprocessingDrug DiscoveryStem Cells
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