PatchXpress 7000A Automated Parallel Patch Clamp System

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Molecular Devices

The first planar patch clamp platform with gigaseal capability has set the standard to which other systems are compared. The PatchXpress® 7000A Automated Parallel Patch Clamp System has revolutionized ion channel drug discovery. With over 13 independent peer reviewed scientific publications, the data quality from the PatchXpress 7000A System is considered to be equivalent to conventional patch clamp-or even better, since it eliminates potential operator bias. The system's rapid compound addition rate (τ=10-15 ms) enables the assay of rapidly desensitizing ligand-gated ion channels, such as the α-7 nicotinic acetylcholine receptor. The independent wash station with individual control for each assay well provides virtually unlimited washout of each recording chamber. This enables the removal of excess cells before the procedure, prevents cumulative desensitization of ligand-gated ion channels, and allows addition of multiple test compounds to the same cell if desired. The use of disposable pipette tips prevents any chance of cross contamination between compound additions, and the optional tip re-use function minimizes non-specific binding of compounds to the pipette tips.