iPS-based Automated Drug Screening: From Human iPS to Midbrain Dopaminergic Neurons

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SELECTBIO

We provide an overview over our methods allowing us to differentiate human neural precursor cells generated from iPS cultures into midbrain dopaminergic neurons in a fully automated fashion. The resulting cell cultures can serve as a scalable disease model for familial Parkinson's disease based on a LRRK2 2019S mutation and allows for screening compounds in a human neural model system.