Using In vitro and In vivo Models to Assess the Local and Systemic Responses to Nanomaterial Exposure

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SELECTBIO

An overview of data describing translocation of nanomaterials following pulmonary, oral and intravenous, delivery and then relating this to local and distal effects (e.g. in the liver) including oxidative stress and inflammatory gene changes. There is an urgent need for better in vitro alternatives for nanomaterial toxicity testing. This study compares local and distal responses with in vitro responses to nanomaterials and identifies scenarios that work, that don’t work and makes suggested changes for the future.