Pathology is Phenotyping. What Do Pathologists Do? How Do they Do It?

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November 18, 2013

Microscopic examination remains the gold standard for classification and staging of cancer and other diseases.  Any diagnostic test that relies on tissue must fit into this work flow.   Histology is the processing of tissue biopsies for microscopic evaluation.  It is crucial to understand how a diagnostic test fits into the landscape of pathology and clinical medicine.  This presentation will include a practical overview of diagnostic pathology as it relates to existing diagnostic tools such as immunohistochemistry and fluorescence in situ hybridization.  Newer diagnostics must find their place in this workflow.  Some rules of the road about diagnostic markers/tests:  they should change clinical practice; tissue houses the most concentrated and unaltered forms of tumor markers; pricing is relevant; pathologists are cost effective – your marker should pick up where they leave off; multiplexing is preferable; they must fit into the existing work flow of histopathology.

Drug DiscoveryGenomicsInformatics

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