Exosomes and Microvesicles in the Circulation

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SELECTBIO

Stress on blood: formation of extracellular vesicles. Blood cells respond to stress with release of extracellular vesicles. In particular red blood cells are prone to vesicle release upon a range of stress signals which can range from mechanical stress (e.g. during cardiopumonary bypass procedures) or chemical stress after pharmaceutical intervention (e.g. Taxol). These vesicles carry phosphatidylserine which is thrombogeneic, and carry iron/heme which can cause oxidative stress.