Biopharmaceutical Evaluation of Poorly Soluble Drugs and Enabling Formulations

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SELECTBIO

Current paradigm of “enabling formulations” is: Poorly soluble drugs may upon solubilization show absorption profiles similar to soluble drugs. Therefore, formulation development aims at robust solubility enhancement. A critical review of common in-vitro approaches and experimental data on solubility / permeability of poorly soluble drugs from enabling formulations is presented.