Secretome Proteomics for Tumor Biomarker Discovery



December 7, 2012

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  • Josep Villanueva, Group Leader, Vall d'Hebron Institute of Oncology (VHIO)

    Tumor cell communication with its microenvironment plays a key role in tumor initiation and progression. Tumor cells hijack the tumor microenvironment ecosystem via paracrine signaling to promote a pro-oncogenic microenvironment that is critical for the establishment of primary and metastatic tumors. Our working hypothesis is that cellular signaling pathways are altered during tumorigenesis and that these alterations are translated into differential protein secretion, which potentially can also be exploited to discover secreted markers. The methodological focus of our group is based on the quantitative profiling of the cancer secretome. The cancer secretome contains secreted proteins that tumor cells use as molecular SMS to communicate with each other and with their microenvironment, and have a high probability of being present in biological fluids. The presentation will focus on new approaches to identify tumor-specific secreted proteins that can be used to monitor key steps in cancer progression.

    Proteomics and Metabolomics

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