Chromatin Remodeling and Epigenetic Control of Cell Differentiation

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SELECTBIO

Karl Ekwall, Professor of Medical Genetics and Epigenetics, Karolinska Institute

Abstract
The great diversity of epigenomes that can arise from a single genome permits a single, cell to generate all the different cell types of an adult individual. The epigenetic changes include modifications of the DNA and histones, and are a prerequisite for cell differentiation. Maintenance of one particular epigenome during chromatin replication is crucial for clonal expansion of cell lineages and tissues. Our laboratory is studying how chromatin-remodeling factors are contributing to epigenetic control mechanisms.