siRNA Sequence Model: Redesign Algorithm Based on Available Genome Wide Libraries Screens

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SELECTBIO

Karol Kozak, Head, Computation Analysis, ETH Zurich

Abstract
Because not all siRNA that are developed to a given target mRNA are equally effective, design tools have been developed based on experimental data to increase the knock-down efficiency of siRNAs. On this talk bioinformatics approach to validate design of siRNA libraries will be presented. New methods for better siRNA sequences will be proposed.