Identification of highly Potent, Short and Stable Chemerin Analogs Using High-content Analysis and Other Cell Based Assays

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Carsten Grotzinger, Group Leader and HeadCharite University Medicine Berlin AbstractCMKLR1 is a GPCR over expressed in squamous cell carcinomas of the esophagus. We have advanced the wild-type C-terminal nonamer peptide of its ligand chemerin into highly stabilized analogues that retain both high affinity and enabled us to generate contrast for tumor imaging.