Metabolomic Biomarkers of Hypoxic Ischaemic Encephalopathy and Perinatal Asphyxia in Umbilical Cord Blood

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January 25, 2012

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  • Peri-natal hypoxic ischemic encephalopathy (HIE) is a condition that occurs when the newborn brain is deprived of an adequate oxygen supply around the time of delivery, and can lead to clinical signs of cerebral injury. Here we present a DI-MS/MS metabolic profiling biomarker study of umbilical cord blood with the ultimate aim of producing quick, cheap, reproducible, non-user dependent mass spectrometer based method for quantifying severity of HIE and enabling rapid therapeutic intervention.

    InformaticsProteomics and Metabolomics

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