Proteomics at High Content using DNA Microarray Technology

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December 15, 2011

We have been able to create a new class of aptamers, called SOMAmers, in which binding specificity for the intended human proteins is remarkably high (equivalent to the pair of antibodies in an ELISA), and we have been able to develop an assay format in which the SOMAmers that bind to their cognate targets are quantified using DNA microarray technology (or QPCR).  In the present version of the assay, inspecting about 1,100 human proteins, we use roughly 15 ml of any complex sample (without depletions of any kind) to determine the concentrations of each protein in the sample. A description of the proteomics assay and a review of SomaLogic’s clinical pipeline will be provided.

Flow Chemistry

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