Use of Mesenchymal Stem Cells for Therapies in the Lung



July 21, 2011

Over the past few years, stem cells has emerged as a possible important therapy on lung disorders. Consistent with this idea, infusion of a specific stem cell populations termed bone marrow derived mesenchymal stem cells (MSCs) appear to be important in the regulation of acute inflammatory process. We are presenting examples of the use of MSC in acute and chronic diseases in the lung. We demonstrated that MSC administration prevented endotoxin induced Acute Lung Injury (ALI), suppressing the endotoxin induced pro-inflammatory cytokines. To demonstrate the clinical relevance of these results, we are presenting new data that will show the association between the ability to induce mobilization of bone marrow derived cells and the survival of patients at the intensive care unit with ALI. Lung transplantation is a viable treatment option for end-stage pulmonary diseases, but development of obliterative bronchiolitis (OB), reduces survival, accounting for 30% of deaths after the third year. In addition, some of the mechanisms used by BMDMSC to control injury will be reviewed.

BioengineeringStem Cells

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