Predicting Hepatotoxicity with CellCiphr HCS technology: Rat and Human Hepatotoxicity Predicton: Validation and Case Studies

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SELECTBIO

De-risking of drug discovery programs is a top concern for most pharmaceutical companies. Reducing the cost of R&D while continuing to bring innovative products to the market sounds difficult if not impossible. In vitro approaches for early detection of mechanisms of toxicity will be presented. Assays and their validation, how they are used in drug-discovery process and how they could be used as part of de-risking the drug candidates will be addressed using CellCiphr high-content imaging platform. We will be discussing strategies of using in vitro toxicology data in combination with bioinformatics platform that allow prediction of safety risk of drug candidates in preclinical and clinical stages.