Autophagy Review



June 19, 2014

An overview of Autophagy, one of the most important biological processes. Autophagy is a cellular degradation process that involves the delivery of cytoplasmic cargo to the lysosome. Autophagy occurs at low basal levels in all cells to maintain homeostatic functions such as protein and organelle turnover. It is rapidly upregulated when cells need to generate intracellular nutrients and energyd during starvation, growth factor withdrawal, or high bioenergetic demands. Autophagy is also important process to dispose of damaging cytoplasmic components during oxidative stress, infectionor protein aggregate accumulation. Consequently, impairment in autophagy can lead todevelopment of certain pathological conditions.

Analytical TechniquesChemistryGenomicsInformatics

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