Reorganization of Pancreas Circadian Transcriptome with Aging | Aging-US

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Aging-US published this research paper on August 29, 2023 in Volume 15, Issue 16, entitled, “Reorganization of pancreas circadian transcriptome with aging" by researchers from the Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL; Division of Allergy and Immunology, Department of Internal Medicine, Rush University Medical Center, Chicago, IL; University of Wisconsin-Parkside, Department: Biological Sciences, Kenosha, WI; Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL; Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL. DOI - https://doi.org/10.18632/aging.204929 Corresponding author - Faraz Bishehsari - Faraz_Bishehsari@rush.edu Abstract The evolutionarily conserved circadian system allows organisms to synchronize internal processes with 24-h cycling environmental timing cues, ensuring optimal adaptation. Like other organs, the pancreas function is under circadian control. Recent evidence suggests that aging by itself is associated with altered circadian homeostasis in different tissues which could affect the organ’s resiliency to aging-related pathologies. Pancreas pathologies of either endocrine or exocrine components are age-related. Whether pancreas circadian transcriptome output is affected by age is still unknown. To address this, here we profiled the impact of age on the pancreatic transcriptome over a full circadian cycle and elucidated a circadian transcriptome reorganization of pancreas by aging. Our study highlights gain of rhythms in the extrinsic cellular pathways in the aged pancreas and extends a potential role to fibroblast-associated mechanisms. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204929 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, circadian rhythms, RNA transcriptomics, pancreas About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM