CDK9 Inhibitors: Promising Combination Partner for Hematological Malignancy Treatment | Oncotarget



August 7, 2023

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  • Oncotarget published this trending research perspective on August 7, 2023 in Volume 14, entitled, “CDK9 INHIBITORS: a promising combination partner in the treatment of hematological malignancies" by researchers from the Division of Hematology, START Madrid-FJD, Hospital Fundación Jiménez Díaz, Madrid, Spain; Division of Oncology, START Madrid-FJD, Hospital Fundación Jiménez Díaz, Madrid, Spain. DOI - Correspondence to - Victor Moreno - Abstract Most hematological malignancies are characterized by overexpression of certain cancer promoting genes, such as MYC, MCL1 and cyclin D1. Preclinical studies in animal models have shown that CDK9 inhibitors supress the transcription of these anti-apoptotic and pro-survival proteins, and suggest their potential synergism with other drugs. In its first in-human trial, enitociclib demonstrated clinical activity in a small cohort of patients with high grade B lymphoma with MYC and BCL2 and/or BCL6 rearrangements, inducing complete responses in 2 of 7 subjects (29%) in monotherapy. These data suggest CDK9 inhibitors could play a role in the treatment of hematological diseases and could be a great ally when combined with other therapeutic approaches. Sign up for free Altmetric alerts about this article - Subscribe for free publication alerts from Oncotarget - Keywords - cancer, cyclin-dependent kinases (CDK), CDK9, hematological malignancies About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit and connect with us: SoundCloud - Facebook - Twitter - Instagram - YouTube - LinkedIn - Pinterest - Reddit - Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

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