Immune Checkpoint Functional Assays

The immune checkpoint is a kind of signal for regulating the antigen recognition of T cell receptor (TCR) in the process of immune response. It can be divided into two types, namely co-stimulatory immune checkpoint and co-inhibitory immune checkpoint (Fig.1). Once the immune system is attacked by pathogens, these immune checkpoint molecules can protect the normal tissues from damage. Over the past several decades, multiple immunotherapy approaches have been developed with the aim to study the ability of an individual’s immune system to attack and destroy tumor cells. Particularly, antibody immunotherapies demonstrate great potential in eliciting durable disease control across a wide spectrum of cancer types, in contrast to the immediate but transient responses induced by conventional targeted therapies. With all these appealing features, immune checkpoint antibodies are gaining increasing popularity and attention as a promising solution for cancer treatment. https://www.creative-biolabs.com/drug-discovery/therapeutics/immunomodulation-function-assay.htm