EGFR Endocytosis: More Than Meets the Eye

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Oncotarget

Oncotarget published this trending editorial perspective on April 10, 2023 in Volume 14, entitled, “EGFR endocytosis: more than meets the eye" by researchers from the Department of Biological Sciences, Middle East Technical University, Dumlupinar Blv No:1, Universiteler Mah., Cankaya, Ankara 06800, Türkiye. DOI - https://doi.org/10.18632/oncotarget.28400 Correspondence to - Ayse Elif Erson-Bensan - erson@metu.edu.tr Abstract Behind the scenes of signaling cascades initiated by activated receptors, endocytosis determines the fate of internalized proteins through degradation in lysosomes or recycling. Over the years, significant progress has been made in understanding the mechanisms of endocytosis and deregulation in disease states. Here we review the role of the EGF-SNX3-EGFR axis in breast cancers with an extended discussion on deregulated EGFR endocytosis in cancer. Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28400 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - EGFR, SNX3, USP32, endocytosis, cancer, breast cancer About Oncotarget Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form, and then quickly released to Pubmed. On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by Medline/PubMed and PMC/PubMed. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957