Body Weight Influences Musculoskeletal Adaptation to Running in Aging Mice

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Aging (Aging-US)

Aging-US published this research paper in Volume 15, Issue 2, entitled, "Body weight influences musculoskeletal adaptation to long-term voluntary wheel running during aging in female mice" by the Department of Anatomy, Cell Biology and Physiology, School of Medicine, Indiana University, Indianapolis, IN; Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri, Kansas City, MO; Bone-Muscle Research Center, College of Nursing and Health Innovation, University of Texas, Arlington, TX; Department of Biostatistics and Health Data Science, School of Medicine, Indiana University, Indianapolis, IN; Department of Biomedical Sciences, School of Medicine, University of Missouri, Kansas City, MO; Department of Orthopaedic Surgery, School of Medicine, Indiana University, Indianapolis, IN. DOI - https://doi.org/10.18632/aging.204390 Corresponding authors - Lynda Bonewald - lbonewal@iu.edu, Michael J. Wacker - wackerm@umkc.edu Abstract Frailty is the hallmark of aging that can be delayed with exercise. The present studies were initiated based on the hypothesis that long-term voluntary wheel running (VWR) in female mice from 12 to 18 or 22 months of age would have beneficial effects on the musculoskeletal system. Mice were separated into high (HBW) and low (LBW) body weight based on final body weights upon termination of experiments. Bone marrow fat was significantly higher in HBW than LBW under sedentary conditions, but not with VWR. HBW was more protective for soleus size and function than LBW under sedentary conditions, however VWR increased soleus size and function regardless of body weight. VWR plus HBW was more protective against muscle loss with aging. Similar effects of VWR plus HBW were observed with the extensor digitorum longus, EDL, however, LBW with VWR was beneficial in improving EDL fatigue resistance in 18 mo mice and was more beneficial with regards to muscle production of bone protective factors. VWR plus HBW maintained bone in aged animals. In summary, HBW had a more beneficial effect on muscle and bone with aging especially in combination with exercise. These effects were independent of bone marrow fat, suggesting that intrinsic musculoskeletal adaptions were responsible for these beneficial effects. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204390 Keywords - body weight, musculoskeletal adaptation, long-term, voluntary wheel running, aging About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://youtube.com/Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM