Psychological Factors Substantially Contribute to Biological Aging in Chinese Cohort

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October 4, 2022

Aging-US published this trending research paper as the cover of Volume 14, Issue 18, entitled, "Psychological factors substantially contribute to biological aging: evidence from the aging rate in Chinese older adults" by researchers from the Deep Longevity Limited, Hong Kong, People's Republic of China; Department of Psychology, Stanford University, Stanford, CA; Department of Psychology, The Chinese University of Hong Kong, Hong Kong, People's Republic of China; Insilico Medicine, Hong Kong, People's Republic of China; Buck Institute for Research on Aging, Novato, CA. DOI - https://doi.org/10.18632/aging.204264 Corresponding authors - Fedor Galkin - fedor@deeplongevity.com Abstract We have developed a deep learning aging clock using blood test data from the China Health and Retirement Longitudinal Study, which has a mean absolute error of 5.68 years. We used the aging clock to demonstrate the connection between the physical and psychological aspects of aging. The clock detects accelerated aging in people with heart, liver, and lung conditions. We demonstrate that psychological factors, such as feeling unhappy or being lonely, add up to 1.65 years to one’s biological age, and the aggregate effect exceeds the effects of biological sex, living area, marital status, and smoking status. We conclude that the psychological component should not be ignored in aging studies due to its significant impact on biological age. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204264 Press release - https://www.aging-us.com/news_room/Psychological-factors-substantially-contribute-to-biological-aging-evidence-from-the-aging-rate-in-Chinese-older-adults Keywords - aging, psychological aging, lifespan psychology, aging clocks, longevity About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/agingus​ LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Analytical TechniquesCell ScienceMolecular BiologyNeuroscience

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