Paper Spotlight: Systemic Lipolysis Promotes Physiological Fitness in Fruit Flies

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Aging (Aging-US)

Aging-US published this trending research paper in Volume 14, Issue 16, entitled, "Systemic lipolysis promotes physiological fitness in Drosophila melanogaster" by researchers the Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA; University of Minnesota Informatics Institute, Minneapolis, MN; Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN; Department of Biology, University of Washington, Seattle, WA; Department of Lab Medicine and Pathology, University of Washington School of Medicine, Seattle, WA; Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, University of Minnesota, Minneapolis, MN. DOI - https://doi.org/10.18632/aging.204251 Corresponding author - Douglas G. Mashek - dmashek@umn.edu Abstract Since interventions such as caloric restriction or fasting robustly promote lipid catabolism and improve aging-related phenotypical markers, we investigated the direct effect of increased lipid catabolism via overexpression of bmm (brummer, FBgn0036449), the major triglyceride hydrolase in Drosophila, on lifespan and physiological fitness. Comprehensive characterization was carried out using RNA-seq, lipidomics and metabolomics analysis. Global overexpression of bmm strongly promoted numerous markers of physiological fitness, including increased female fecundity, fertility maintenance, preserved locomotion activity, increased mitochondrial biogenesis and oxidative metabolism. Increased bmm robustly upregulated the heat shock protein 70 (Hsp70) family of proteins, which equipped the flies with higher resistance to heat, cold, and ER stress via improved proteostasis. Despite improved physiological fitness, bmm overexpression did not extend lifespan. Taken together, these data show that bmm overexpression has broad beneficial effects on physiological fitness, but these effects did not impact lifespan. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204251 Press release - https://www.aging-us.com/news_room/Systemic-lipolysis-promotes-physiological-fitness-in-Drosophila-melanogaster Keywords - aging, brummer, lipolysis, physiological fitness, stress resistance, proteostasis About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/agingus​ LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM