Trending With Impact: Resveratrol Treatment Restored Quality of Oocytes in Aging Mice

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Aging (Aging-US)

Aging-US published this trending research paper on July 8, 2022 in Volume 14, Issue 14, entitled, "Short-term resveratrol treatment restored the quality of oocytes in aging mice" by researchers from the Department of Obstetrics and Gynecology, International University of Health and Welfare School of Medicine, Chiba 286-8686, Japan; Department of Biodesign, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University Chiyoda-ku, Tokyo 101-0062, Japan; Department of Obstetrics and Gynecology, Juntendo University Faculty of Medicine Bunkyo-ku, Tokyo 113-8421, Japan; Aging Stress Response Project Team, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan. DOI - https://doi.org/10.18632/aging.204157 Corresponding author - Kazuhiro Kawamura - k.kawamura.aq@juntendo.ac.jp Abstract The quality of oocytes declines by aging, resulting in their low competences for fertility. Here, resveratrol treatment showed increases in the rates of implantation and live offspring as well as decreases in the abortion rate as short as one week after treatment, although the number of ovulated oocytes and the rates of fertilization and blastocyst formation were not changed following resveratrol treatment. Resveratrol treatment did not cause abnormalities mouse estrous cycles and body weights. No abnormality was detected in both fetuses and placentas after 22 weeks of resveratrol treatment and the fetuses had normal fertility. Positive correlations were found between serum resveratrol levels and pregnancy and live offspring rates as well as ovarian expression levels of Sirt1, Sirt3, Sirt4, Sirt5, and Sirt7. The mitochondrial membrane potential and ATP content but not copy number of mitochondrial DNA in oocytes was increased in aging mice with resveratrol treatment. In conclusion, we demonstrated the restoration of oocyte quality in aging mice in addition to the prevention of their quality decline during aging by restoring mitochondrial functions by resveratrol treatment without adverse effects in the animals and their offspring. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204157 Keywords - aging, resveratrol, age-associated infertility, oocyte quality, Sirtuin, mitochondria About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/agingus​ LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM