Trending With Impact: An Investigation of Post-COVID-19 Biomarkers

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March 9, 2022

Aging (Aging-US) published this trending research paper in Volume 14, Issue 4, entitled, “Elevated levels of serum CDCP1 in individuals recovering from severe COVID-19 disease” by researchers from the Servicio de Enfermedades Infecciosas, Hospital Universitario San Pedro, Logroño, La Rioja, Spain; Centro de Investigación Biomédica de La Rioja, Logroño, La Rioja, Spain; Instituto Maimónides de Investigación Biomédica de Córdoba, Universidad de Córdoba, Córdoba, Spain; Servicio de Neumología, Hospital Universitario Reina Sofía, Córdoba, Spain; Servicio de Medicina Interna, Hospital Costal de Sol, Marbella, Málaga, Spain; Servicio de Enfermedades Infecciosas, HCU Lozano Blesa, Zaragoza, Spain; Servicio de Enfermedades Infecciosas, H Universitario Marqués de Valdecilla, Santander, Spain; Unidad de Enfermedades Infecciosas, Hospital General Universitario Reina Sofía de Murcia, Murcia, Spain; Servicio de Medicina Interna, Hospital Universitario de Burgos, Burgos, Spain; Vitro Laboratory, Madrid, Spain; Servicio de Radiología, Hospital Universitario Reina Sofía, Córdoba, Spain; Servicio de Neumología, Hospital Costal de Sol, Marbella, Málaga, Spain; Servicio de Neumología, HCU Lozano Blesa, Zaragoza, Spain; Servicio de Neumología, H Universitario Marqués de Valdecilla, Santander, Spain; Servicio de Neumología, Hospital General Universitario Reina Sofía de Murcia, Murcia, Spain; Servicio de Neumología, Hospital Universitario de Burgos, Burgos, Spain; Grupo PBM, Instituto de Investigación-IdiPaz, Madrid, Madrid, Spain; Universidad Rey Juan Carlos, Madrid, Madrid, Spain; Servicio de Neumología, Hospital Universitario San Pedro, Logroño, La Rioja, Spain. DOI - https://doi.org/10.18632/aging.203898 Corresponding Author - Jose-Ramon Blanco - jrblancoramos@gmail.com; https://orcid.org/0000-0002-4268-0150 Abstract Background: COVID-19 survivors report residual lung abnormalities after discharge from the hospital. The aim of this study was to identify biomarkers in serum and induced sputum samples from patients after hospitalization for COVID-19. Methods: Patients admitted to hospitals in Spain with laboratory-confirmed COVID-19 were recruited for this study. SARS-CoV-2-infected patients were divided into groups with mild/moderate and severe disease according to the severity of their symptoms during hospitalization. Levels of 92 biomarkers were measured in serum and induced sputum samples. Results: A total of 108 patients (46.2% severe cases) were included in this study. The median number of days after the onset of symptoms was 104. A significant difference was observed in diffusing capacity for carbon monoxide (DLCO), an indicator of lung function, whereby DLCO <80% was significantly lower in severe cases (p <0.001). Differences in inflammatory biomarkers were observed between patients with mild/moderate and severe disease. For some biomarkers, correlations in serum and induced sputum levels were detected. Independent predictors of severe disease were DLCO <80% and the serum CDCP1 value. Conclusions: Higher levels of CDCP1 remain after hospital discharge and are associated with the severity of COVID-19. The possible prognostic implications warrant further investigation. Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.203898 Keywords - biomarkers, CDCP1, recovery, COVID-19 About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at http://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/agingus​ LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Analytical TechniquesGenomicsImmunology

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