Trending With Impact: Work-Related Stress and Biomarkers of Aging



February 23, 2022

Aging (Aging-US) published this trending research paper on February 2, 2022 in Volume 14, Issue 3, entitled, “Work-related stress and well-being in association with epigenetic age acceleration: A Northern Finland Birth Cohort 1966 Study” by researchers from the MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Campus, London W2 1PG, United Kingdom; Laboratory of Biostatistics, Department of Biomedical Sciences, University of Sassari, Sassari 07100, Italy; Department of Epidemiology, Local Health Unit TO 3, Turin 10095, Italy; School of Educational Sciences and Psychology, University of Eastern Finland, Joensuu FI-80101, Finland; Division of Insurance Medicine, Karolinska Institutet, Stockholm 17177, Sweden; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu 90014, Finland; Grantham Institute for Climate Change and School of Public Health, Imperial College London, London SW7 2AZ, United Kingdom; IIGM – Italian Institute for Genomic Medicine (IIGM), IRCCS Candiolo, Torino 10060, Italy. DOI - Corresponding author - Anna Freni-Sterrantino - Abstract Recent evidence indicates consistent association of low socioeconomic status with epigenetic age acceleration, measured from DNA methylation. As work characteristics and job stressors are crucial components of socioeconomic status, we investigated their association with various measures of epigenetic age acceleration. The study population included employed and unemployed men and women (n=604) from the Northern Finland Birth Cohort 1966. We investigated the association of job strain, effort-reward imbalance and work characteristics with five biomarkers of epigenetic aging (Hannum, Horvath, PhenoAge, GrimAge, and DunedinPoAm). Our results indicate few significant associations between work stress indicators and epigenetic age acceleration, limited to a range of ±2 years, and smoking recording the highest effect on GrimAge age acceleration biomarker between current and no smokers (median difference 4.73 years (IQR 1.18, 8.41). PhenoAgeAA was associated with job strain active work (β=-1.301 95%CI -2.391, -0.212), slowing aging of less than 1.5 years, and working as white-collar slowed aging six months (GrimAgeAA β=-0.683, 95%CI -1.264, -0.102) when compared to blue collars. Association was found for working for more than 40 hours per week that increased the aging over 1.5 years, (HorvathAA β =2.058 95%CI 0.517,3.599, HannumAA β=1.567, 95%CI 0.415,2.719). The pattern of associations was different between women and men and some of the estimated effects are inconsistent with current literature. Our results provide the first evidence of association of work conditions with epigenetic aging biomarkers. However, further epidemiological research is needed to fully understand how work-related stress affects epigenetic age acceleration in men and women in different societies. Sign up for free Altmetric alerts about this article - Keywords - epigenetic age, job strain, effort-reward imbalance, work-related well-being, DNA methylation About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at​​ and connect with us: SoundCloud - Facebook - Twitter - Instagram - YouTube -​ LinkedIn - Pinterest - Aging-US is published by Impact Journals, LLC:​​ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

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