Paper Spotlight: Genomic and Neoantigen Evolution in Head, Neck Cancer



January 12, 2022

Oncotarget published this trending research paper chosen as the cover for Volume 12, Issue 6, entitled, "Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma," by researchers from the Division of Medical Oncology, Washington University in St. Louis, St. Louis, MO; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO; Department of Pathology and Cell Biology, Columbia University, New York, NY; Division of Hematology/Oncology, Columbia University, New York, NY; Department of Genetics, Washington University in St. Louis, St. Louis, MO; Division of Pediatric Hematology and Oncology, St. Louis Children’s Hospital, St. Louis, MO; Siteman Cancer Center, St. Louis, MO. Abstract: Head and neck cell squamous-cell carcinomas (HNSCC) are a group of common cancers typically associated with tobacco use and human papilloma virus infection. Up to half of all cases will suffer a recurrence after primary treatment. As such, new therapies are needed, including therapies which promote the anti-tumor immune response. Prior work has characterized changes in the mutation burden between primary and recurrent tumors; however, little work has characterized the changes in neoantigen evolution. We characterized genomic and neoantigen changes between 23 paired primary and recurrent HNSCC tumors. Twenty-three biopsies from patients originally diagnosed with locally advanced disease were identified from the Washington University tumor bank. Whole exosome sequencing, RNA-seq, and immunohistochemistry was performed on the primary and recurrent tumors. Within these tumors, we identified 6 genes which have predicted neoantigens in 4 or more patients. Interestingly, patients with neoantigens in these shared genes had increased CD3+ CD8+ T cell infiltration and duration of survival with disease. Within HNSCC tumors examined here, there are neoantigens in shared genes by a subset of patients. The presence of neoantigens in these shared genes may promote an anti-tumor immune response which controls tumor progression. Press release - Sign up for free Altmetric alerts about this article - DOI - Full text - Correspondence to - Brian A. Van Tine - Keywords - head and neck squamous cell carcinoma, neoantigens, mutational evolution, tumor relapse, immune cell infiltration About Oncotarget: Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit or follow us: SoundCloud - @oncotarget Facebook - Twitter - LinkedIn - Instagram - YouTube - Pinterest - Reddit - Oncotarget is published by Impact Journals, LLC please visit or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957x105

Cancer ResearchDiagnosticsImmunologyMolecular Biology

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