Trending With Impact: Promising Drugs Repurposed to Treat Oral Mucositis

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Oncotarget

Oncotarget published this trending review on October 26, 2021, entitled, "Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy" by researchers from the Laboratory of Biomineralization, Institute of Biomedical Sciences, Health Sciences Center, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Laboratory of Immunopathology, Institute of Biophysics Carlos Chagas Filho, Health Sciences Center, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Laboratory of Catalysis for Polymerization, Recycling and Biodegradable Polymers (LCPRB), Institute of Macromolecules Professor Eloisa Mano (IMA), Technological Center, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Laboratory of Immunophysiology, Institute of Biomedical Sciences, Health Sciences Center, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Abstract: Clinical guidelines for oral mucositis (OM) still consist in palliative care. Herein, we summarize cellular and molecular mechanisms of OM ulceration in response to chemical therapies in animal models. We discuss evidenced anti-inflammatory and anti-oxidant drugs which have not been ever used for OM, such as synthetic peptides as well as cell therapy with mesenchymal stem cells; amniotic membranes, mucoadhesive polymers loaded with anti-inflammatory agents and natural or synthetic electrospun. These approaches have been promising to allow the production of drug-loaded membranes, scaffolds for cells encapsulation or guided tissue regeneration. Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28091 DOI - https://doi.org/10.18632/oncotarget.28091 Full text - https://www.oncotarget.com/article/28091/text/ Correspondence to - Valeria De Mello-Coelho - coelhova@histo.ufrj.br Keywords - oral mucositis, inflammation, regeneration, polymers, tissue engineering About Oncotarget Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/c/OncotargetYouTube/ LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957