Top-Performer: Hyperbaric Oxygen Yields Cognitive Benefits in Healthy Older Adults



June 15, 2021

Aging published this high-scoring research paper on June 26, 2020, entitled, “Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial,” by researchers from the Shamir Medical Center, Zerifin, Israel; Tel-Aviv University, Tel-Aviv, Israel; Bar Ilan University, Ramat-Gan, Israel. Abstract: More than half of community-dwelling individuals sixty years and older express concern about declining cognitive abilities. The current study’s aim was to evaluate hyperbaric oxygen therapy (HBOT) effect on cognitive functions in healthy aging adults. A randomized controlled clinical trial randomized 63 healthy adults (>64) either to HBOT(n=33) or control arms(n=30) for three months. Primary endpoint included the general cognitive function measured post intervention/control. Cerebral blood flow (CBF) was evaluated by perfusion magnetic resonance imaging. There was a significant group-by-time interaction in global cognitive function post-HBOT compared to control (p=0.0017). The most striking improvements were in attention (net effect size=0.745) and information processing speed (net effect size=0.788). Voxel-based analysis showed significant cerebral blood flow increases in the HBOT group compared to the control group in the right superior medial frontal gyrus (BA10), right and left supplementary motor area (BA6), right middle frontal gyrus (BA6), left middle frontal gyrus (BA9), left superior frontal gyrus (BA8) and the right superior parietal gyrus (BA7). In this study, HBOT was shown to induce cognitive enhancements in healthy aging adults via mechanisms involving regional changes in CBF. The main improvements include attention, information processing speed and executive functions, which normally decline with aging. To date, this study has generated an Altmetric Attention Score of 111. The Altmetric Attention Score provides an at-a-glance indication of the volume and type of online attention the research has received. Top Aging publications rated by Altmetric Attention Score - Sign up for free Altmetric alerts about this article - DOI - Full text - Correspondence to: Amir Hadanny email: and Shai Efrati email: Keywords: cognitive, hyperbaric oxygen, perfusion, cerebral blood flow, aging About Aging Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at​​ or connect with us on: Twitter -​ Facebook -​ SoundCloud -​ YouTube -​ LinkedIn -​ Aging is published by Impact Journals, LLC please visit​​ or connect with @ImpactJrnls Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

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