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Trending with Impact: Biomarkers of Aging and Lung Function in the Normative Aging Study



June 10, 2021

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  • Aging published this research paper on June 19, 2020, entitled, “Biomarkers of aging and lung function in the normative aging study” by researchers from the Harvard T.H. Chan School of Public Health, Boston, MA; Icahn School of Medicine at Mount Sinai, New York, NY; Harvard T.H. Chan School of Public Health, Boston, MA; Northwestern University, Chicago, IL; VA Boston Healthcare System, Boston, MA; Boston University School of Medicine, Boston, MA; Columbia University, New York, NY. Abstract: Elderly individuals who are never smokers but have the same height and chronological age can have substantial differences in lung function. The underlying biological mechanisms are unclear. To evaluate the associations of different biomarkers of aging (BoA) and lung function, we performed a repeated-measures analysis in the Normative Aging Study using linear mixed-effect models. We generated GrimAgeAccel, PhenoAgeAccel, extrinsic and intrinsic epigenetic age acceleration using a publically available online calculator. We calculated Zhang’s DNAmRiskScore based on 10 CpGs. We measured telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN) using quantitative real-time polymerase chain reaction. A pulmonary function test was performed measuring forced expiratory volume in 1 second / forced vital capacity (FEV1/FVC), FEV1, and maximum mid-expiratory flow (MMEF). Epigenetic-based BoA were associated with lower lung function. For example, a one-year increase in GrimAgeAccel was associated with a 13.64 mL [95% confidence interval (CI), 5.11 to 22.16] decline in FEV1; a 0.2 increase in Zhang’s DNAmRiskScore was associated with a 0.009 L/s (0.005 to 0.013) reduction in MMEF. No association was found between TL/mtDNA-CN and lung function. Overall, this paper shows that epigenetics might be a potential mechanism underlying pulmonary dysfunction in the elderly. Sign up for free Altmetric alerts about this article - DOI - Full text - Correspondence to: Cuicui Wang email: Keywords: pulmonary health, DNA methylation, biological clock, aging About Aging Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at​​ or connect with us on: Twitter -​ Facebook -​ SoundCloud -​ YouTube -​ LinkedIn -​ Aging is published by Impact Journals, LLC please visit​​ or connect with @ImpactJrnls Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

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