Trending with Impact: Humanin (Peptide) Regulates Lifespan and Healthspan

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June 4, 2021

Aging published this priority research paper on June 23, 2020, entitled, “The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan” by researchers from University of Southern California, Los Angeles, CA; The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA; The Barshop Institute, University of Texas Health at San Antonio, TX; National Institute on Aging, Dickerson, MD; Calico Life Sciences, South San Francisco, CA; Keck School of Medicine, USC, Los Angeles, CA; Albert Einstein College of Medicine, Bronx, NY; Faculty of Natural Science, University of Haifa, Haifa, Israel; University of Pennsylvania, Philadelphia, PA. Abstract: Humanin is a member of a new family of peptides that are encoded by short open reading frames within the mitochondrial genome. It is conserved in animals and is both neuroprotective and cytoprotective. Here we report that in C. elegans the overexpression of humanin is sufficient to increase lifespan, dependent on daf-16/Foxo. Humanin transgenic mice have many phenotypes that overlap with the worm phenotypes and, similar to exogenous humanin treatment, have increased protection against toxic insults. Treating middle-aged mice twice weekly with the potent humanin analogue HNG, humanin improves metabolic healthspan parameters and reduces inflammatory markers. In multiple species, humanin levels generally decline with age, but here we show that levels are surprisingly stable in the naked mole-rat, a model of negligible senescence. Furthermore, in children of centenarians, who are more likely to become centenarians themselves, circulating humanin levels are much greater than age-matched control subjects. Further linking humanin to healthspan, we observe that humanin levels are decreased in human diseases such as Alzheimer’s disease and MELAS (Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like episodes). Together, these studies are the first to demonstrate that humanin is linked to improved healthspan and increased lifespan. Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.103534 DOI - https://doi.org/10.18632/aging.103534 Full text - https://www.aging-us.com/article/103534/text Correspondence to: Kelvin Yen email: kelvin.yen@usc.edu Keywords: mitochondria, aging, peptides, humanin About Aging Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at http://www.Aging-US.com​​ or connect with us on: Twitter - https://twitter.com/AgingJrnl​ Facebook - https://www.facebook.com/AgingUS/​ SoundCloud - https://soundcloud.com/aging-us​ YouTube - https://www.youtube.com/agingus​ LinkedIn - https://www.linkedin.com/company/aging​ Aging is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​​ or connect with @ImpactJrnls Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Molecular Biology

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