Disease Modeling Using ALI Tools and Systems



June 3, 2021

Air-liquid Interface (ALI) is ideal for studying respiratory tract epithelial cells because it exposes one side of the culture to liquid media and surrounds the other with air. ALI systems therefore allow researchers to more accurately mimic in vivo conditions compared to using conventional cell culture models. This makes them ideal to perform mechanistic studies of respiratory epithelial cells as drug permeation barriers, to model respiratory diseases like cystic fibrosis and asthma, to investigate essential dermal processes such as wound healing and to advance understanding of respiratory epithelium infections, including SARS-CoV-2. From asthma to COPD, ALI models have been critical in researching respiratory diseases. With the recent outbreak and severity of the COVID-19 virus, this technology is becoming even more critical in the race to understand and treat disease. With the popularity of these more complex models growing, join this Teach Me in 10 session to hear Corning Life Sciences Digital Manager Roxana Ghadessy and Corning Life Sciences Product Line Manager Shabana Islam talk to us about disease modeling using ALI tools and systems. For more information on ALI tools, be sure to check out the following resources: https://www.corning.com/catalog/cls/documents/application-notes/CLS-AN-527.pdf https://www.corning.com/catalog/cls/documents/application-notes/CLS-AN-493.pdf https://www.corning.com/catalog/cls/documents/application-notes/CLS-AN-599.pdf https://www.corning.com/catalog/cls/documents/citations-references/CLS-AN-605.pdf https://www.corning.com/worldwide/en/products/life-sciences/resources/stories/the-cutting-edge/tissue-engineering-the-latest-3d-cellular-models-for-respiratory-drug-development.html https://www.corning.com/worldwide/en/products/life-sciences/resources/stories/in-the-field/using-air-liquid-interface-in-your-research.html https://www.biocompare.com/Bench-Tips/564894-Uses-and-Best-Practices-for-Air-Liquid-Interface-Systems/#:~:text=Air%2Dliquid%20interface%20(ALI),of%20multi%2Dlayered%20skin%20models https://www.corning.com/worldwide/en/products/life-sciences/applications/disease-modeling/air-liquid-interface.html

Analytical TechniquesCell ScienceDiagnosticsDrug Discovery

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