The Epigenetic Clock, Aging, and Rejuvenation

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Aging (Aging-US)

In a trending research perspective published by Aging on February 24, 2021, entitled, “Aging and rejuvenation - a modular epigenome model,” researchers examined the role that the epigenetic clock may play in the aging process and in rejuvenation as an approach to set back epigenetic age. A centenarian is a human that has lived as long or longer than one hundred years. These individuals are marvels to aging researchers and have been studied at length in hopes of uncovering clues about the mechanisms that drive aging. Many researchers have crafted views and theories about the roots of gerontology; these curiosities have preceded the development of modern science. In an effort to describe different views and theories of aging—leading to the emergent view of the epigenome as the driver of aging—researchers from the National University of La Plata, National University of Cordoba, World Academy of Art and Science, and Betterhumans Inc., authored a research perspective published by Aging. “The hypothesis proposing the epigenome as the driver of aging was significantly strengthened by the converging discovery that DNA methylation at specific CpG sites could be used as a highly accurate biomarker of age defined by the Horvath clock.” To date, this study has generated an Altmetric Attention Score of 34. The Altmetric Attention Score provides an at-a-glance indication of the volume and type of online attention the research has received. Top Aging publications rated by Altmetric score - https://www.aging-us.com/news_room/altmetric Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.202712 DOI - https://doi.org/10.18632/aging.202712 Full text - https://www.aging-us.com/article/202712/text Correspondence to: Rodolfo G. Goya email: goya@isis.unlp.edu.ar Keywords: aging, DNA methylation, epigenetic clock, rejuvenation, cell reprogramming About Aging Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at http://www.Aging-US.com​​ or connect with us on: Twitter - https://twitter.com/AgingJrnl​ Facebook - https://www.facebook.com/AgingUS/​ SoundCloud - https://soundcloud.com/aging-us​ YouTube - https://www.youtube.com/agingus​ LinkedIn - https://www.linkedin.com/company/aging​ Aging is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​​ or connect with @ImpactJrnls Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM