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Application of Microfluidic 3D Liver Chip Models for Genotoxity Testing: Go With the Flow

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January 28, 2021

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  • Current in vitro pre-clinical genetic toxicology tools used to determine drug metabolism and genotoxicity consist of a metabolic activation system (induced rat S9 mix) and single cells. The low concordance between rat and human metabolism is a potential cause for the low predictive power of rat models for human liver toxicity in clinical trials. This webinar will detail the current challenges in the field of integrating microphysiological systems with classic genetic toxicology and will describe advancements made in the Genetic Toxicology Department-Charles River Montreal to successfully tackle these endeavors.

    Cell ScienceDrug DiscoveryGenomics

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