Analyzing the SARS-CoV-2 Glycan Shield With Mass Spec

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January 27, 2021

Scientists worldwide are working tirelessly to develop a vaccine for SARS-CoV-2 (the COVID-19 betacoronovirus), focusing on the humoral immune response to the spike (S) glycoprotein. Understanding the S protein’s glycosylation can reveal fundamental features of viral biology for use in the development and manufacturing of serological testing kits and potential vaccines. In this webinar, Max Crispin and Joel Allen will share how they characterized both the site-specific N-linked glycan composition and the degree of sequon occupancy on a soluble, native-like SARS-CoV-2 S protein. The sequon occupancy likely plays a role in immune evasion and occlusion of immunogenic proteins. Marshall Bern of Protein Metrics will also share how Protein Metrics’ advanced analytical software contributes detailed benchmarking of virus glycosylation.

ImmunologyMass SpectrometryProteomics and Metabolomics

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