ADME 101 In Vitro Enzyme Induction Studies Overview



August 19, 2020

Presenter: Andrew Taylor, Ph.D., Services Technical Support Manager

The clearance of a drug can be increased and its effectiveness or safety compromised if it is co-administered with a second drug that induces the enzyme responsible for its metabolism, which is why regulatory agencies highlight the importance of studies to evaluate this potential cause of drug-drug interactions. This 20 minute overview features:
- An overview of enzyme induction
- Why is measuring CYP (or other enzyme) induction important?
- Regulatory guidance & expectations
- Types of induction studies
- Typical study design (definitive vs. screening)
- Considerations & questions to ask upfront
- Test systems for induction studies and more...

You may also want to view the more in-depth webinar: In Vitro Induction Studies: Elements of Design and Important Considerations in Data Analysis, presented by Joanna Barbara, Ph.D., Vice President of Scientific Operations at SEKISUI XenoTech.

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About the presenter: Dr. Andrew G. Taylor received his Ph.D. from University of California San Diego. He joined SEKISUI XenoTech as a research scientist in 2017, serving as a Study Director in nonclinical drug interaction contract studies in compliance with Good Laboratory Practices (GLP), OECD Principles of GLP, &/or Japan MOHW GLP Standards and specializing in drug transport and drug metabolism studies. He became the Technical Support Manager for services in 2020 and provides valuable guidance to ensure research needs are being met.

Cancer ResearchDrug DiscoveryMass Spectrometry

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