Cannabinoid Remediation and Purification from Hemp by Centrifugal Partition Chromatography

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August 7, 2020

Speaking at The Science of Cannabis Extraction Online Symposium 2020 in June, Lauren Kaiser of Platinum Sponsor Gilson presented her talk on remediation and purification of cannabinoids from lab to production scale. Abstract: Centrifugal partition chromatography (CPC) is a liquid-liquid partition chromatography technique that provides an efficient, streamlined workflow for natural product purification. Hemp, grown primarily for industrial purposes, encompasses cultivars of Cannabis sativa that are low in tetrahydrocannabinol (THC) content. Following harvest and extraction, a mixture of cannabinoids, including THC, remains in the valuable product. CPC is then employed to accomplish several key goals: (1) remediate THC to below the legal limit or non-detectable levels, (2) purify minor cannabinoids (CBC, CBN, CBG, etc.) to produce high purity isolates, and (3) remediate pesticides. CPC purification methodology is optimized at the lab and/or pilot scale and linearly transitioned to production scale on a Gilson VERITY CPC Process System. Key advantages of CPC include: no product loss, absence of solid stationary support, easy recycling of solvents to keep operating costs low compared to other chromatography techniques, and flexibility to develop new methods to match evolving goals in an ever-changing market.

Analytical TechniquesCannabis ScienceChromatographyMass Spectrometry

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