Stable Isotope Labeling

Stable isotope labeling using amino acids in cell culture (SILAC) is a powerful method based on mass spectrometry that identifies and quantifies relative differential changes in protein abundance. First used in quantitative proteomics in 2002, it provides accurate relative quantification without any chemical derivatization or manipulation. https://www.creative-proteomics.com/services/silac-based-proteomics-analysis.htm